Symbol
Name
ID

H2-Ab1
histocompatibility 2, class II antigen A, beta 1
MGI:103070

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgA level

Polyclonal elevation of IgM

Decreased circulating antibody level

Secretory IgA deficiency

Eosinophilia

Increased T cell count

Lymphopenia

Leukocytosis

Leukopenia

Abnormal lymphocyte morphology

Abnormal granulocyte morphology

Abnormal basophil morphology

Acute lymphoblastic leukemia

Ph-positive acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemias

Acute myeloid leukemia

Chronic myelogenous leukemia

Myeloproliferative disorder

Autoimmune thrombocytopenia

Keratoconjunctivitis

Keratoconjunctivitis sicca

Pericarditis

Abnormal lymph node morphology

Lymphadenopathy

Thymoma

Abnormality of the spleen

Asplenia

Splenic infarction

Splenomegaly

Hepatosplenomegaly

Ulcerative colitis

Celiac disease

Recurrent infection of the gastrointestinal tract

Helicobacter pylori infection

Hepatitis

Chronic hepatitis

Subacute progressive viral hepatitis

Pancreatitis

Otitis media

Chronic otitis media

Thyroiditis

Keratitis

Scleritis

Uveitis

Iridocyclitis

Epididymitis

Lupus nephritis

Nephritis

Abnormality of the immune system

Recurrent cutaneous abscess formation

Eczematoid dermatitis

Erythema nodosum

Psoriasiform dermatitis

Chronic mucocutaneous candidiasis

Chronic intestinal candidiasis

Discoid lupus rash

Maculopapular exanthema

Malar rash

Myositis

Osteomyelitis

Pneumonia

Serositis

Decreased circulating complement C3 concentration

Decreased circulating complement C4 concentration

Autoimmunity

Autoimmune antibody positivity

Anti-citrullinated protein antibody positivity

Anti-desmoglein-1 antibody positivity

Anti-desmoglein-3 antibody positivity

Antineutrophil antibody positivity

Perinuclear antineutrophil antibody positivity

Antinuclear antibody positivity

Anti-dsDNA antibody positivity

Anti-La/SS-B antibody positivity

Anti-Sm antibody positivity

Anti-U1 ribonucleoprotein antibody positivity

Antiphospholipid antibody positivity

Lupus anticoagulant

Platelet antibody positive

Rheumatoid factor positive

Systemic lupus erythematosus

Immunodeficiency

Asthma

Recurrent infections

Recurrent bacterial infections

Recurrent respiratory infections

Recurrent bronchitis

Recurrent sinopulmonary infections

Disease(s) Associated with HLA-DQB1

achalasia

acute lymphoblastic leukemia

acute myeloid leukemia

allergic bronchopulmonary aspergillosis

alopecia areata

antiphospholipid syndrome

asthma

autoimmune disease

autoimmune polyendocrine syndrome type 2

autoimmune thrombocytopenic purpura

Behcet's disease

beta thalassemia

chronic myeloid leukemia

common variable immunodeficiency

hepatocellular carcinoma

IgA glomerulonephritis

immunoglobulin alpha deficiency

myasthenia gravis

mycosis fungoides

myositis

paroxysmal nocturnal hemoglobinuria

pemphigus vulgaris

pre-eclampsia

primary sclerosing cholangitis

rheumatoid arthritis

sarcoidosis

sickle cell anemia

Sjogren's syndrome

systemic lupus erythematosus

type 1 diabetes mellitus

Mouse Phenotypes

immune system phenotype

insulitis

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

increased double-negative T cell number

increased B cell number

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

decreased CD4-positive, alpha-beta T cell number

absent CD4-positive, alpha-beta T cells

increased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased regulatory T cell number

decreased single-positive T cell number

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology

abnormal spleen morphology

abnormal spleen B cell follicle morphology

absent spleen germinal center

abnormal spleen marginal zone morphology

abnormal spleen periarteriolar lymphoid sheath morphology

abnormal lymphocyte physiology

abnormal B cell physiology

abnormal immunoglobulin level

decreased IgG1 level

decreased IgG level

decreased IgM level

increased IgM level

abnormal T cell physiology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T cell activation

abnormal macrophage antigen presentation

abnormal immune system morphology

abnormal immune system cell morphology

abnormal immune system organ morphology

abnormal lymph node cell ratio

abnormal immune system physiology

abnormal professional antigen presenting cell physiology

abnormal dendritic cell physiology

abnormal dendritic cell antigen presentation

abnormal level of surface class II molecules

decreased level of surface class II molecules

abnormal humoral immune response

abnormal cytokine secretion

decreased interleukin-12 secretion

decreased tumor necrosis factor secretion

autoimmune response

decreased susceptibility to autoimmune disorder

decreased susceptibility to experimental autoimmune encephalomyelitis

decreased susceptibility to experimental autoimmune myasthenia gravis

increased anti-erythrocyte antigen antibody level

increased anti-double stranded DNA antibody level

increased anti-single stranded DNA antibody level

decreased susceptibility to parasitic infection

increased susceptibility to parasitic infection

abnormal response to transplant

Availability

Mouse Genotype

H2-Ab1^b-tm1.1Jssh/H2-Ab1^b-tm1.1Jssh

H2-Ab1^b-tm1.1Sish/H2-Ab1^b-tm1.1Sish

H2-Ab1^b-tm1Doi/H2-Ab1^b-tm1Doi

H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru

H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru
Tg(Ab1TL)1Gru/0

H2-Ab1^b-tm1Wug/H2-Ab1^b-tm1Wug

H2-Ab1^bm12/H2-Ab1^bm12

H2-Ab1^g7-em1Ygch/H2-Ab1^g7-em1Ygch

H2-Ab1^b-tm1Doi/H2-Ab1⁺

H2-Ab1^b-tm1Wug/H2-Ab1^b-tm1Wug
Cd19^tm1(cre)Cgn/Cd19⁺ (conditional)

H2-Ab1^b-tm1Koni/H2-Ab1^b-tm1.1Koni
Tg(Tek-cre)12Flv/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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